Pathophysiological defects in familial hypertriglyceridaemia and familial combined hyperlipidaemia.
Familial hypertriglycendaemia is primarily due to overproduction of triglycerides, whereas familial combined hyperlipidaemia is primarily characterised by increased production of apo B. Both lead to an increased input of VLDL into plasma, although the composition of the VLDL particles differs in the two disorders.
